Drug delivery systems for DED in the market or under clinical investigation.
Commercial Product Main Ingredient Drug Delivery Method Company Time to
Market
Restasis® Cyclosporine A, Polysorbate, Castor Oil, Carbomer, etc. O/W anionic nanoemulsion Allergan, Irvine, CA, USA December 2002
Cationorm® Mineral Oil, Glycerin, Tyloxapol, Poloxamer 188, etc. O/W cationic nanoemulsion Santen Pharmaceutical, Osaka, Japan May 2008
Tears Again® Soy Lecithin, Sodium Chloride, Vitamin A, Palmitic Acid and Vitamin E, etc. Liposome spray Optima
Pharmaceutical, Hallbergmoos, Germany September 2008
Soothe XP® Light Mineral Oil (1.0%), Boric Acid, Mineral Oil (4.5%), etc. O/W anionic nanoemulsion Bausch & Lomb, Clearwater, FL, USA May 2010
Mucosta® Rebamipide, polyvinyl alcohol, sodium citrate hydrate, sodium chloride. Suspension Otsuka Pharmaceutical, Tokyo, Japan January 2012
Ikervis® Cyclosporine A, Medium Chain Triglycerides, Glycerin, Tyloxapol, etc. O/W cationic nanoemulsion Santen Pharmaceutical, Osaka, Japan March 2015
Cequa® Cyclosporine A, polyoxyethylene hydrogenated castor oil, etc. Nanomicelle Sun Pharmaceutical, Mumbai, India August 2018
EYSUVIS® 0.25% Loteprednol Etabonate, etc. Nanosuspension Kala Pharmaceuticals, Arlington, MA, USA October 2020
Tyrvaya® varenicline water-based nasal spray Oyster Point Pharmaceutical, Princeton, NJ, USA October 2021
VisuEvo® omega-3s, vitamins A and D, and phospholipids, etc. Liposomes Visufarma SpA, Rome, Italy Clinical Trials
VisuXL® Coenzyme Q10, Vitamin E TPGS and Sodium Carboxymethylcellulose. Hydrogel Visufarma SpA, Rome, Italy Clinical Trials
NOV 03® Perfluorohexyloctane Anhydrous Drug Delivery System Novaliq, Baden-Wurttemberg, Germany Clinical Trials
CyclASol® 0.1% Cyclosporine A, Semifluorinated alkane Anhydrous Drug Delivery System Novaliq, Baden-Wurttemberg, Germany Clinical Trials